Product IntroductionBioactivity英文名:
GW590735描述: GW590735 是一种有效的选择性 PPARα 激动剂,对 PPARα 的 EC50 为 4 nM,比 PPARδ 和 PPARγ 的选择性至少高 500 倍。 GW590735 可用于血脂异常研究。
体内活性: GW590735 (2 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 13 mL/min/kg, 2.8 L/kg, 2.6 hours and 85%, respectively in dogs while GW590735 (2.7 mg/kg; i.v.) shows Cl, Vd, T1/2, and F% are 5 mL/min/kg, 1 L/kg, 2.4 hours and 47%, respectively in rats. In male C
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (104.5 mM)
关键字:
lipid |
LDLc |
GW590735 |
HDLc |
Peroxisome proliferator-activated receptors |
PPAR |
imbalance |
GW 590735 |
GW-590735 |
Inhibitor |
inhibit |
triglycerides |
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