来曲唑，112809-51-5，98%

中文名：来曲唑

英文名：Letrozole

中文别名：来曲唑|来曲唑|4,4'-(1H-1,2,4-三唑-1-基亚甲基)双苄腈|4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

英文别名：letrozole|112809-51-5|Femara|4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile|Letrozol|CGS 20267|Letoval|CGS-20267|Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-|4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile|4-[(4-cyanophenyl)-(1,2,4-t

纯度：98%

货号：L129473

Cas号：112809-51-5

存储温度：-20°C储存

产品介绍：

Letrozole has been used:

· in organoid growth assay to determine its inhibitory capacity(48)

·  to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49)

·  to determine its effects on tumor-induced hyperalgesia(50)

·  for hormonal manipulation in rats(51)

·  to study its effects on lipocalin-2 (Lcn2)(52)

·  to determine its effects on mechanical hyperalgesia and aromatase expression(53)

Letrozole是非甾体类芳香酶抑制剂，其 IC50 为1-13 nM；是第三代aromatase抑制剂，无细胞试验中IC50为0.07-20 nM。在临床研究中，对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用，不影响正常的尿电解质排泄或甲状腺功能。