毛钩藤碱 TN1065
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Product IntroductionBioactivity英文名: Hirsutine描述: Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血
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Product Introduction
Bioactivity
英文名: Hirsutine
描述: Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
体外活性: The clinical utility of Hirsutine against human breast cancer. Among six distinct human breast cancer cell lines, Hirsutine showed strong cytotoxicity against HER2-positive/p53-mutated MDA-MB-453 and BT474 cell lines. Conversely, HER2-negative/p53 wild-type MCF-7 and ZR-75-1 cell lines showed resistance against Hirsutine-induced cytotoxicity. Hirsutine induced apoptotic cell death in the MDA-MB-453 cells, but not in the MCF-7 cells, through activation of caspases. Furthermore, Hirsutine induced the DNA damage response in the MDA-MB-453 cells, but not in the MCF-7 cells, as highlighted by the upregulation of γH2AX expression. Along with the induction of the DNA damage response, the suppression of HER2, NF-κB and Akt pathways and the activation of the p38 MAPK pathway in the MDA-MB-453 cells were observed[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (135.7 mM)
关键字: inhibit | Hirsutine | Apoptosis | Inhibitor
相关产品: β-Elemonic Acid | GSK2656157 | Sandacanol | Mivebresib | Sophoraflavanone G | Diffractaic Acid | Ritonavir | D609 | Samuraciclib hydrochloride | PBOX 6
相关库: Anti-Tumor Natural Product Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Covalent Natural Product Library | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Miao medicine Compound Library | Covalent Inhibitor Library | Natural Product Library
Bioactivity
英文名: Hirsutine
描述: Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
体外活性: The clinical utility of Hirsutine against human breast cancer. Among six distinct human breast cancer cell lines, Hirsutine showed strong cytotoxicity against HER2-positive/p53-mutated MDA-MB-453 and BT474 cell lines. Conversely, HER2-negative/p53 wild-type MCF-7 and ZR-75-1 cell lines showed resistance against Hirsutine-induced cytotoxicity. Hirsutine induced apoptotic cell death in the MDA-MB-453 cells, but not in the MCF-7 cells, through activation of caspases. Furthermore, Hirsutine induced the DNA damage response in the MDA-MB-453 cells, but not in the MCF-7 cells, as highlighted by the upregulation of γH2AX expression. Along with the induction of the DNA damage response, the suppression of HER2, NF-κB and Akt pathways and the activation of the p38 MAPK pathway in the MDA-MB-453 cells were observed[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (135.7 mM)
关键字: inhibit | Hirsutine | Apoptosis | Inhibitor
相关产品: β-Elemonic Acid | GSK2656157 | Sandacanol | Mivebresib | Sophoraflavanone G | Diffractaic Acid | Ritonavir | D609 | Samuraciclib hydrochloride | PBOX 6
相关库: Anti-Tumor Natural Product Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Covalent Natural Product Library | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | Apoptosis Compound Library | Miao medicine Compound Library | Covalent Inhibitor Library | Natural Product Library
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