Product Introduction
Bioactivity


英文名: Batatasin III

描述: Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。

体内活性: Batatasin III may impose a lethal effect on the aquatic fauna in small streams. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests[1]. Batatasin III significantly suppresses mesenchymal transition indicated by the decrease of N-cadherin and Vimentin and up-regulation of E-cadherin[1]. Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Focal adhesion kinase | Batatasin III | Inhibitor | inhibit | PTK2 protein tyrosine kinase 2 | PKB | FAK | PTK2 | Protein kinase B | Akt

相关产品: Masitinib | CEP-37440 | FAK-IN-12 | Masitinib mesylate | YH-306 | AZ7550 | Compound 1T-0219 (SC) | 2119738-71-3 | Inulicin | PF-562271

相关库: RO5 Drug-like Natural Product Library | Rare Natural Product Library