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Product IntroductionBioactivity英文名: Chimonanthine描述: (-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects o
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Product Introduction
Bioactivity
英文名: Chimonanthine
描述: (-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
体外活性: From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-Chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), and (-)-calycanthidine (3, 1.8 μM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Chimonanthine
Bioactivity
英文名: Chimonanthine
描述: (-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
体外活性: From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-Chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), and (-)-calycanthidine (3, 1.8 μM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Chimonanthine
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