Product Introduction
Bioactivity


英文名: Mesaconine

描述: Mesaconine 是来自 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有心脏作用和抗 NF-κB 活性。 Mesaconine 可能是麻黄附子细辛汤抗炎和免疫抑制的部分物质基础。

体外活性: SFI的抗炎作用在体外通过内皮细胞验证。在检测细胞活性后，从上清液中确定了白细胞介素-6（IL-6）、核因子kappa-B激酶的抑制剂（IKK）、磷酸化IKK、磷酸化NF-κB以及磷酸化IκB-α的表达。SFI能显著抑制炎症反应，其机制可能通过NF-κB依赖的途径。Mesaconine是首个报道具有NF-κB抑制活性的SFI化合物[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (113.27 mM)


关键字: Inhibitor | inhibit | Mesaconine

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