Product Introduction
Bioactivity


英文名: Tetrahydrocannabivarin

描述: Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂，对 2 型糖尿病有潜在治疗价值。

体外活性: 在3-1000纳摩尔（nM）的浓度范围内，THCV并没有阻止小鼠离体输精管的电刺激引起的收缩；然而，此范围内的THCV浓度在WIN和阿纳米德对电刺激引发收缩的对数浓度-反应曲线中形成向右的偏移。这些变化并未伴随任何激动剂的最大效应降低。尽管如此，当浓度达到3毫摩尔（mM）时，THCV以一种与CB1受体拮抗剂（SR141716）无关的方式减少了输精管的收缩反应。此外，THCV类似于SR141716拮抗剂，在高浓度下也与非CB1目标产生相互作用。[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: O-4394 | inhibit | THC-V | Cannabinoid Receptor | Tetrahydrocannabivarin | Inhibitor | O4394 | O 4394

相关产品: MJ 15 | yangonin | BAY 38-7271 | CB2 modulator 1 | GW842166X | CB2R/FAAH modulator-1 | 6-Iodopravadoline | Bay 59-3074 | EHP-101 | CB2 receptor agonist 2

相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Antidepressant Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compound Library