Product IntroductionBioactivity英文名:
Bruceantinol B描述: Bruceantinol B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6643,CAS号为 1822332-33-1。
体外活性: Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro. METHODS AND RESULTS: Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, Bruceantinol B and bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, bruceantinol, and yadanziolide A were isolated. CONCLUSIONS: Antibabesial activities were also examined in vitro, and bruceine A and bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC50 = 103 ng/mL) used clinically against B. gibsoni, with IC50 values of 4 and 12 ng/mL, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bruceantinol B