Product Introduction
Bioactivity


英文名: Lumicitabine

描述: Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.

动物实验: Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2].

体内活性: In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 48 mg/mL (110.63 mM)


关键字: Lumicitabine | ALS8176 | ALS 8176 | ALS008176 | ALS 008176

相关产品: Palivizumab | Ac-CoA Synthase Inhibitor1 | RSV-IN-1 | RSV604 | Rilematovir | RSV L-protein-IN-4 | AVG-233 | Amentoflavone | Quercetin pentaacetate | Roflumilast