中文名：2,4＇-二溴苯乙酮

英文名：2,4'-Dibromoacetophenone

中文别名：4-溴苯甲酰甲基溴|4'-溴苯甲酰甲基溴

英文别名：2,4'-Dibromoacetophenone|99-73-0|2-Bromo-1-(4-bromophenyl)ethanone|p-Bromophenacyl bromide|4-Bromophenacyl bromide|Ethanone, 2-bromo-1-(4-bromophenyl)-|2-bromo-1-(4-bromophenyl)-ethanone|2-bromo-1-(4-bromophenyl)ethan-1-one|4'-Bromophenacyl bromide|132309

纯度：98%

货号：D113568

Cas号：99-73-0

存储温度：2-8°C储存,避光

产品介绍：

GSK-3β Inhibitor VII is a phenyl α-bromomethyl ketone compound which acts as a cell-permeable, and non-ATP competitive inhibitor of glycogen synthase kinases (GSK-3&beta); (IC = 0.5 μM). This compound acts as an alkylating agent that is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM. Research has shown that glycogen synthase kinases have major roles in Wnt and Hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. This pertinent biological activity makes GSK inhibitors very useful research molecules.A cell-permeable, and non-ATP competitive inhibitor of GSK-3β

应用：

在 SnCl2 或 SmI3 存在的情况下与醛发生缩合反应以生成 α,β-不饱和酮。还用于羧酸的酯化反应。

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