中文名:靛玉红
英文名:Indirubin
中文别名:靛红
英文别名:(3Z)-3-(3-oxoindolin-2-ylidene)indolin-2-one|2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-, (3E)-|AKOS032455876|KBioGR_000450|DB12379|(3E)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one|HMS2234G06|KBioSS_000450
纯度:分析标准品,≥98%
货号:I140424
Cas号:479-41-4
存储温度:2-8°C储存
产品介绍:
Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10μM), CDK2/cyclin A (IC50 = 2.2μM), CDK2/cyclin E (IC50 = 7.5μM), CDK4/cyclin D1 (IC50 = 12μM), CDK5/p35 (IC50 = 5.5μM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model. An inhibitor of GSK-3β and cyclin-dependent kinases.
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