中文名：N,N,2-三甲基-5-硝基苯磺酰胺

英文名：N,N,2-Trimethyl-5-nitrobenzenesulfonamide

英文别名：433695-36-4|BRL-50481|BRL 50481|N,N,2-trimethyl-5-nitrobenzenesulfonamide|5-Nitro-2,N,N-trimethylbenzenesulfonamide|N,N,2-Trimethyl-5-nitro-benzenesulfonamide|Benzenesulfonamide, N,N,2-trimethyl-5-nitro-|BRL50481|CHEMBL484928|N,N,2-trimethyl-5-nitrobenzen

纯度：≥98%

货号：B137236

Cas号：433695-36-4

存储温度：2-8°C储存

产品介绍：

BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies sμggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frμgiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.

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