中文名：丹磺胺

英文名：Dansylcadaverine

中文别名：丹酰尸胺|N-(二甲基氨基萘磺酰)-1,5-戊二胺|N-(5-氨基戊基)-5-二甲基氨基萘-1-磺酰胺

英文别名：Dansylcadaverine|10121-91-2|monodansylcadaverine|Monodansyl cadaverine|n-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide|1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)-|N-(5-Aminopentyl)-5-(dimethylamino)naphthalene-1-sulphonamid

纯度：≥97%

货号：D131032

Cas号：10121-91-2

存储温度：-20°C储存,充氩

产品介绍：

Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throμghout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping throμgh the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods.A fluorescent amine probe.Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used: · as an endocytosis inhibitor in human proximal tubular HK-2 cells, mouse J774A.1 macrophages and human A549 epithelial cells · to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies · in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples.

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