中文名：盐酸白屈菜红碱

英文名：Chelerythrine chloride

中文别名：白屈菜赤碱

英文别名：Chelerythrine chloride|3895-92-9|1,2-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride|Chelerythrine hydrochloride|Chelerythrine (chloride)|7IC98TZ0PZ|CHEMBL258893|1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthr

纯度：98%

货号：D133831

Cas号：3895-92-9

存储温度：-20°C储存

产品介绍：

Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is throμgh the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also throμgh inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.A potent and selective inhibitor of protein kinase C.

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