中文名：普卡酶素

英文名：Plicamycin

中文别名：光辉酶素,金霉酸|Mithramycin A|普卡霉素|光辉霉素

英文别名：MITHRAMYCIN|plicamycin|Mithracin|mithramycin a|Aureolic acid|18378-89-7|Mithramycinum|Mithramycine|Plicamycine|Plicamycinum|Mitramycin|Aurelic acid|CHEBI:31856|Antibiotic LA 7017|CHEMBL257619|NIJ123W41V|Mitramycine|Mitramycinum|Aurlelic acid|A-2371|Plicam

纯度：≥95%

货号：P113149

Cas号：18378-89-7

存储温度：-20°C储存,充氩

产品介绍：

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cellsA polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent

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