产品性能
人蛋白质：20,240种
一张芯片上的点阵数目：1
点样环境：温度4-8℃，湿度30%~40%
芯片基片：PATH，尺寸为75*25 mm
点直径：~60微米
样品重复：每个样品重复两个点
点体积：0.5~1 nl/点
芯片点制后处理：4℃过夜固定后-80℃长期保存
产品应用
1. 药物作用靶标发现及药物作用机理研究
2. 蛋白质-蛋白质相互作用研究
3. 蛋白质翻译后修饰研究
4. 非编码RNA作用机制研究
5. 蛋白质与DNA相互作用研究
6. 抗体特异性筛选
7. 酶底物研究发表的文章
Yang, Lina, et al. "Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray." Molecular & Cellular Proteomics (2015): mcp-M115. [PubMed]
Zhang, Hai-nan, et al. "Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic." Proceedings of the National Academy of Sciences 112.49 (2015): 15084-15089. [PubMed]
Hu, C et al. (2015) Autoantibody Profiling on Human Proteome Microarray for Biomarker Discovery in Cerebrospinal Fluid and Sera of Neuropsychiatric Lupus. PLoS One 10:e0126643.[PubMed]
Liu, S et al. (2015) Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119. [PubMed]
Fan, Q et al. (2014). Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124. [PubMed]
Deng, RP et al. (2014). Global Identification of O-GlcNAc Transferase (OGT) Interactors by a Human Proteome Microarray and the Construction of an OGT Interactome.Proteomics 14(9): 1020-30. doi: 10.1002/pmic.201300144. Epub 2014 Mar 25.0.[PubMed]
Ma, TM et al. (2014) Serine Racemase Regulated by Binding to Stargazin and PSD-95: Potential NMDA-AMPA Glutamate Neurotransmission Cross-talk. J Biol Chem pii: jbc.M114.571604. [Epub ahead of print]; First Published on August 27, 2014. [PubMed]
Barry G et al. (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molec Psychiatry Apr 30. doi: 10.1038/mp.2013.45. ePub ahead of print.[PubMed]
Lee YI et al. (2013). Protein microarray characterization of the S-nitrosoproteome. Mol Cell Proteomics 13:63-72. [PubMed]
Chen Y et al. (2013). Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Mol Cell Proteomics 12(10):2804-19.[PubMed]
Donnelly CJ et al. (2013). RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80(2):415-28. [PubMed]
Fan B et al. (2013). A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA. Mol Cell Proteomics. 13(1):84-92. [PubMed]
Tarrant MK et al. (2012). Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol 8(3):262-9. [PubMed]
Jeong JS et al. (2012). Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253.[PubMed]
Huang Y. et al. (2012). Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. Cell Cycle 11(12):2367-79. [PubMed]
Hu CJ et al. (2012). Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Mol Cell Proteomics 11(9):669-80. [PubMed]
