产品名称：Recombinant Bovine CD14 Protein

规格或纯度：无动物源, 无载体, ≥95%(SDS-PAGE)

生化机理：CD14 is a 55 kDa cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. The human CD14 cDNA encodes a 375 amino acid (aa) residue precursor protein with a 19 aa signal peptide and a C-terminal hydrophobic region characteristic for glycosylphosphatidyinositol (GPI)-anchored proteins. Human CD14 has four potential N-linked glycosylation sites and also bears O-linked carbohydrates. The amino acid sequence of human CD14 is approximately 65% identical with the mouse, rat, rabbit, and bovine proteins. CD14 is a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS-binding protein (LBP). The toll-like-receptors have also been implicated in the transduction of CD14-LPS signals. Similar to other GPI-anchored proteins, soluble CD14 can be released from the cell surface by phosphatidyinositol-specific phospholipase C. Soluble CD14 has been detected in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS-mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.

应用：SDS-PAGE, Functional Studies

氨基酸：1-373 aa

无载体：Yes

无动物源：Yes

Accession #：Q95122

预测分子量：40.5 kDa

SDS-PAGE：43.9-52.5 kDa, under reducing conditions; 41.9-49.3 kDa, under non-reducing conditions.

级别：无动物源, 无载体

储存缓冲液：Lyophilized from PBS, pH 7.4.

复溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存温度：-20°C储存,避免反复冻融

运输条件：超低温冰袋运输

稳定性与储存：Store at -20°C for 1 year. Avoid freeze/thaw cycle.

Accession #：Q95122

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