产品名称：Recombinant Human YOD1 Protein

规格或纯度：无载体, ≥95%(SDS-PAGE), 见COA

生化机理：Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

应用：SDS-PAGE, Functional Studies

氨基酸：2-348 aa

无载体：Yes

无动物源：No

Accession #：Q5VVQ6

预测分子量：39.1 kDa

SDS-PAGE：42.1 kDa, under reducing conditions; 42.2 kDa, under non-reducing conditions.

级别：无载体

储存缓冲液：20mM Tris, 300M NaCl, 1mM DTT, 0.5% Tween 80, 0.5mM EDTA, 10% Trehalose, 50% Glycerol, pH 8.0.

浓度：见COA

储存温度：-20°C储存,避免反复冻融

运输条件：超低温冰袋运输

稳定性与储存：Store at -20°C for 1 year. Avoid freeze/thaw cycle.

Accession #：Q5VVQ6

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