2-(2,6-二氯苯氨基)苯乙酸，15307-86-5，Moligand™, ≥98%

中文名：2-(2,6-二氯苯氨基)苯乙酸

英文名：Diclofenac

纯度：Moligand™, ≥98%

货号：D155733

Cas号：15307-86-5

存储温度：2-8°C储存

产品介绍：

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drμg (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thoμght to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Diclofenac (双氯芬酸) 是COX抑制剂，对绵羊的COX-1和-2的IC50分别为60和220 nM。

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