In Vitro: Mesotrione is a potent HPPD enzyme inhibitor, giving an estimated Ki value in the range 6±18pM at 25°C. HPPD is from Arabidopsis thaliana (L).
In Vivo: Mesotrione (oral administration; 1 mg/kg; single dose) is rapidly and extensively absorbed in rats and mice. After a single dose, the urinary excretione is estimated, the urinary excretione estimated absorption values ranged from 62.2% in males and 68.3% in females. The mean peak blood concentration (Cmax) of radioactivity occurred 0.5 hours after dosing in each sex.