MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 73803-48-2
MCE 国际站:Tripamide
产品活性:Tripamide 是一种具有口服活性磺胺类可利尿的降压试剂 (antihypertensive agent)。
研究领域:Membrane Transporter/Ion Channel
作用靶点:Potassium Channel
In Vitro: Tripamide (less than 10 μg/ml) does not modify the membrane potential and resistance, but does suppress the spike evoked by outward current pulses in the presence of 3-5 mM TEA.In the mesenteric artery, Tripamide suppresses the amplitude of e.j.ps evoked by perivascular nerve stimulation. However, the facilitation process produced by repetitive stimulation is less affected by Tripamide.
In Vivo: In rats loaded orally with 25 ml/kg of normal saline, Tripamide (0.6-160 mg/kg) increases urine volume and sodium and chloride excretion in a dose-dependent fashion. Only at a dose of 160 mg/kg, there an increase in potassiumexcretion in rats.Tripamide has anti-hypertensive effects, during administration to spontaneously hypertensive rats at a dose of 10 mg/kg/day for 4 weeks, tripamide doubled urine volume and sodium excretion, while potassium excretion is increased by <50% in rats.
相关产品:Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Orally Active Compound Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Potassium Channel Compound Library | Heterocyclic Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Mitiglinide-d5 calcium | Ropivacaine hydrochloride | WX-081 | Doxapram hydrochloride hydrate | TASK-1-IN-1 | Tamapin | VU0134992 | BL-1249 | Dendrotoxin K | Disopyramide | Domiphen bromide | 20(S)-Ginsenoside Rg3 | AZD-5672 | Daurisoline | (+)-KCC2 blocker 1 | ML252 | Budiodarone | Ketanserin | AMP-PNP tetralithium | PK-THPP | Ifenprodil tartrate | DDO-02005 | Hydrochlorothiazide-13C6 | Brompheniramine maleate | Meclofenamic acid sodium hydrate | DMP-543 | BAPTA-AM | PNU 37883 hydrochloride
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。