HY-150618HY-150618 PI3Kα-IN-9 | MedChemExpress (MCE)
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规格 |
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5 mg |
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PI3Kα-IN-9
CAS No. : 2715287-67-3
MCE 国际站:PI3Kα-IN-9
产品活性:PI3Kα-IN-9 (compound 27) 是一种有选择性的口服长效 PI3Kα 抑制剂 (PI3Kα inhibitor),对于 PI3Kα、PI3Kγ、PI3Kδ 和 PI3Kβ,其 IC50 值分别为 4.4、128、146 和 153 nM。PI3Kα-IN-9 具有抗增殖活性并诱导细胞凋亡。PI3Kα-IN-9 可用于癌症研究。
研究领域:PI3K/Akt/mTOR | Apoptosis
In Vitro: PI3Kα-IN-9 (compound 27) (0-8 μM; 72 hours; cancer cell lines) has antiproliferative activity and induces apoptosis.
PI3Kα-IN-9 (compound 27) (0-8 μM; MGC-803 cells) down-regulates the expression of PI3Kα protein, the proteins of PI3K downstream, p-AKT and p-P70S6 K.
In Vivo: PI3Kα-IN-9 (compound 27) (1-10 mg/kg; p.o. and i.v.; for 24 hours; male Sprague-Dawley rat) has favorable stability (T1/2>10 h) and high bioavailability (130%).
PI3Kα-IN-9 (compound 27) (30 mg/kg; p.o.; daily, for 3 weeks; male BALB/c nude mice) has antitumor activity and low cytotoxicity.
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