In Vitro: ERK-IN-4 (Compound 76; 10-75 µM; 10 days) completely inhibits cell proliferation, and decreases number of cell colonies. ERK-IN-4 (Compound 76; 100 µM) inhibits ERK-mediated phosphorylation of Rsk-1 on Thr573 and ERK-mediated Elk-1 phosphorylation in HeLa cells.