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MCE 国际站:Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His)
Acetyl-CoA synthetase 1/AceCS Protein, Mouse (His) 是一种将乙酸转化为乙酰辅酶 A 的酶,通过在压力条件下捕获乙酸作为碳源为肿瘤细胞提供乙酰辅酶 A。
Synonyms: Acss2; Acas2; Acecs1Acetyl-coenzyme A synthetase; cytoplasmic; EC 6.2.1.1; Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acetyl-CoA synthetase 1; AceCS1
Species: Mouse
Source: E. coli
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:Acetyl-CoA synthetase 2 (ACSS2), an enzyme that converts acetate to acetyl-CoA, imparts a competitive growth advantage under conditions of metabolic stress by enhancing the ability of cancer cells to use acetate as an additional nutritional source when other carbon sources are scarce or cannot be used to sustain lipid biomass production. The activity of ACSS2 contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. The downregulation of ACSS2 expression is a metabolic hallmark of tumor progression and aggressive behavior in colorectal carcinoma.
蛋白编号:Q9QXG4 (M1-Q701)
基因 ID:60525
产品分类:酶和调节子 | 连接酶
Categories:Enzymes & Regulators | Ligases (EC 6)
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