P413931-200mgPF-CBP1盐酸，2070014-93-4，≥96%
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- 生产商
- P413931-200mg
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| 规格 |
|---|
| 200mg |
中文名：PF-CBP1盐酸
英文名：PF-CBP1 HCl
纯度：≥96%
货号：P413931
Cas号：2070014-93-4
存储温度：-20°C储存
产品介绍：
Information
PF-CBP1 HCl PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP) .It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
Targets
CREBBP (Cell-free assay); p300/CBP (Cell-free assay) 125nM; 363nM
In vitro
PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson\'s disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high.
Cell Research(from reference)
Cell lines：mouse J774 macrophage-like cell line
Concentrations：0.1-10\xa0μM
Incubation Time：30min
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