Q127558-5mgQuizartinib (AC220)
面议
- 阿拉丁
- 生产商
- Q127558-5mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C29H32N6O4S
- 分子量560.68
属性
溶解性 | DMSO 33.2 mg/mL; Water <0.3 mg/mL; Ethanol <0.5 mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | An Flt-3/Flk-2 inhibitor. |
产品介绍 | Quizartinib (AC220)是一种二代FLT3抑制剂,作用于Flt3(ITD/WT),IC50为1.1 nM/4.2 nM,作用于Flt3比作用于KIT, PDGFRA, PDGFRB, RET,和CSF-1R选择性高10倍。Phase 3。 |
备注 | Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2. |
生化机理 | Quizartinib, Free Base, is an fms-related tyrosine kinase 3 (FLT3) receptor tyrosine kinase inhibitor. In binding assays, quizartinib has demonstrated a high affinity for FLT3 (Kd = 1.6 nM). in vitro assays examining FLT3 internal tandem duplicate mutations and wild-type FLT3 demonstrate the ability of quizartinib to inhibit FLT3 autophosphorylation (IC50 = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). Quizartinib, Free Base, has also been shown to inhibit the growth of human leukemia cell line MV4-11 (IC50 = 0.56 nM) and A375 cells (IC50 > 10,000 nM). |
别名 | N-(5-叔丁基异恶唑-3-基)-N'-{4-[7-[2-(吗啉-4-基)乙氧基]咪唑并[2,1-b][1,3]苯并噻唑-2-基]苯基}脲;AC-220; AC220;N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea |
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