N127052-100mgBGJ398 (NVP-BGJ398)
面议
- 阿拉丁
- 生产商
- N127052-100mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C26H31Cl2N7O3
- 分子量560.48
属性
溶解性 | DMSO 1 mg/mL heating (1 mM);Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM) |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent and selective inhibitor of Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4. |
产品介绍 | BGJ398 (NVP-BGJ398)是一种有效的,选择性的FGFR抑制剂,作用于FGFR1/2/3,IC50为0.9 nM/1.4 nM/1 nM,作用于FGFR比作用于FGFR4和VEGFR2选择性高40倍以上,对Abl, Fyn, Kit, Lck, Lyn和Yes几乎没有抑制活性。Phase 2。 |
备注 | BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. |
生化机理 | BGJ398 is a potent and selective fibroblast growth factor receptor family inhibitor for Flg (FGFR-1), Bek (FGFR-2), FGFR-3 and FGFR-4. |
别名 | BGJ-398;BGJ 398;NVP BGJ398;3-(2,6-二氯-3,5-二甲氧基苯基)-1-[6-[[4-(4-乙基哌嗪-1-基)苯基]氨基]嘧啶-4-基]-1-甲基脲;3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea;Infigratinib |
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