A129309-50mgApoptosis Activator 2
面议
- 阿拉丁
- 生产商
- A129309-50mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C15H9Cl2NO2
- 分子量306.14
属性
敏感性 | 对光敏感 |
溶解性 | Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.; DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度 2-8°C |
描述
应用 | An indoledione caspase activator |
产品介绍 |
Apoptosis Activator 2强诱导caspase-3激活, PARP分裂, DNA断裂,导致细胞破坏(Apaf-1依赖性的),IC50约为4 μM,抑制HMEC, PREC和MCF-10A细胞活性。 |
备注 | Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
生化机理 | Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3. |
别名 | 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮;凋亡活化剂 2;1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione |
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