A127799-50mgBarasertib (AZD1152-HQPA)
面议
- 阿拉丁
- 生产商
- A127799-50mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C26H30FN7O3
- 分子量507.56
- MDL号 MFCD10687152
属性
沸点 | 796.7° C at 760 mmHg |
折光率 | 1.68 |
溶解性 | DMSO ≥100mg/mL Water ≥100mg/mL Ethanol ≥2.8mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | A highly selective ARK-2 inhibitor |
产品介绍 | AZD1152-HQPA是AZD-1152的活性代谢物,AZD1152-HQPA (Barasertib)是Aurora B 高选择性抑制剂,IC50为0.37 nM,比对Aurora A的抑制性高100倍。 |
备注 | AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold more selective for Aurora B over Aurora A. |
生化机理 | AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines. |
别名 | AZD1152; AZD 1152; 5-((7-(3-(乙基(2-羟基乙基)氨基)丙氧基)-4-喹唑啉)氨基)-N-(3-氟苯基)-1H-吡唑-3-乙酰胺;;Barasertib;5-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-1h-pyrazole-3-acetamide;3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide |
猜你喜欢
感兴趣产品