D129714-25mg17-DMAG (Alvespimycin) HCl
面议
- 阿拉丁
- 生产商
- D129714-25mg
- 现货
- 全国
规格 |
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耗材描述
属性
溶解性 | DMSO 131 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | An Hsp90 inhibitor |
产品介绍 | 17-DMAG (Alvespimycin) HCl是一种有效的,水溶性HSP90抑制剂,IC50为62 nM。 |
备注 | 17-DMAG is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM. |
生化机理 | 17-DMAG, Hydrochloride Salt is a water-soluble analog of 17-AAG and geldanamycin . 17-DMAG, Hydrochloride Salt binds the ATP binding site of Hsp90 and inhibits its chaperone activity. It displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). |
别名 | NSC 707545;阿螺旋霉素盐酸盐;NSC 707545;Alvespimycin hydrochloride |
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