S125104-1mgScriptaid
面议
- 阿拉丁
- 生产商
- S125104-1mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C18H18N2O4
- 分子量326.35
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. |
生化机理 |
A novel HDAC inhibitor, Scriptaid, has been found to have robust activity and lower toxicity compared to trichostatin A (TSA). Although Scriptaid induced activation of both p38MAPK and JNK, it was the inhibition of JNK that attenuated Scriptaid-induced apoptosis significantly. Scriptaid also increased the expression of (i) p21 and p27 involved in cell-cycle regulation and (ii) γH2AX associated with DNA damage response in a JNK-dependent manner. |
别名 | Scriptide, GCK 1026;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-;Scriptide, GCK 1026;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo- |
猜你喜欢
感兴趣产品