O126162-1gOlaparib (AZD2281, Ku-0059436)
面议
- 阿拉丁
- 生产商
- O126162-1g
- 现货
- 全国
规格 |
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耗材描述
属性
溶解性 | Soluble in DMSO (33 mg/mL), ethanol (1.7 mg/mL), and water (<1 mg/mL) at 25 °C. |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent inhibitor of PARP |
产品介绍 | Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂,IC50为5 nM/1 nM,比对Tankyrase-1的作用强300倍。 |
备注 | Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1. Phase 1/2. |
生化机理 | Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways |
别名 | KU-0059436;奥拉帕尼; 1-(环丙甲酰基)-4-[5-[(3,4-二氢-4-氧代-1-酞嗪基)甲基]-2-氟苯甲酰]哌嗪;AZD2281;KU-0059436;KU0059436;AZD-2281;KU0059436;AZD 2281;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine |
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