C127191-250mgCUDC-101
面议
- 阿拉丁
- 生产商
- C127191-250mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C24H26N4O4
- 分子量434.49
属性
溶解性 | DMSO ≥40mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
存贮条件 | 储存温度-20°C |
描述
应用 | A potent inhibitor of HDACs and receptor tyrosine kinases |
产品介绍 | CUDC-101是HDAC,EGFR和HER2抑制剂,IC50分别为4.4,2.4和15.7 nM。 |
备注 | CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. |
生化机理 | CUDC-101 inhibits the erlotinib-resistant EGFR mutant T790M although its effects are incomplete with an Amax of ~60% of peak enzyme activity after inhibition. CUDC-101 treatment increases the acetylation of histone H3 and H4, as well as the acetylation of non-histone substrates of HDAC such as p53 and α-tubulin, in a dose-dependant manner in various cancer cell lines. CUDC-101 also suppresses HER3 expression, Met amplification, and AKT reactivation in tumor cells. |
别名 | 7-((4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基)氧基)-N-羟基庚酰胺;;CUDC101;CUDC 101;7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-n-hydroxyheptanamide |
猜你喜欢
感兴趣产品