A129838-5mgAM1241
面议
- 阿拉丁
- 生产商
- A129838-5mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C22H22IN3O3
- 分子量503.33
- Beilstein号
- EC号 MFCD11045986
- MDL号
- PubChem编号
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | (R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models |
产品介绍 | AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. |
备注 | AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. |
生化机理 | AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAMP assay when forskolin concentration is lowered. In [3H]CP 55,940 competition binding assays, AM-1241 displays high affinity at the human CB2 receptor with a Ki value of about 7 nM, whereas its affinity at the human CB1 receptor is more than 80-fold weaker, using membrane preparations from stable HEK and CHO cell lines expressing the recombinant human CB2 and CB1 receptors, respectively. |
别名 | ((R,S)-AM 1241; (R,S)-3-(2-碘-5-硝基苯甲酰)-1-(1-甲基-2-哌啶甲基)-1H-吲哚;(R,S)-AM1241; (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole |
信号词 | Danger |
危害声明 | H315-H319-H334-H335 |
警示性声明 | P261-P305 + P351 + P338-P342 + P311 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
WGK德国 | 3 |
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