L126616-5mgLY335979

耗材描述

• 分子式 C₃₂H₃₁F₂N₃O₂.3HCl
• 分子量637

属性

溶解性	Soluble in DMSO (100 mg/mL at 25 °C), water (23 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and methanol.
存贮条件	储存温度-20°C

描述

应用	A modulator of Pgp.
产品介绍	Zosuquidar (LY335979) 3HCl是一种有效的P-glycoprotein（P-糖蛋白）介导的多药耐抗性的调节剂，Ki为60 nM。Phase 3。
备注	Zosuquidar (LY335979) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
生化机理	Zosuquidar trihydrochloride is a potent modulator of P-glycoprotein-mediated(Mdr-1) multidrug resistance. This compound exhibits an IC50=60 nM. Zosuquidar trihydrochloride competitively inhibits equillibrium binding of drugs to Mdr-1 and shows an ability to reverse drug resistance to multiple oncolytics.
别名	Zosuquidar 三盐酸盐;(2R)-1-{4-[(1aR,6r,10bS)-1,1-二氟-1,1a,6,10b-四氢二苯并[a,e]环丙并[c]环庚烯-6-基]哌嗪-1-基}-3-(喹啉-5-基氧基)丙-2-醇三盐酸盐;RS 33295-198; Zosuquidar trihydrochloride;LY335979;LY-335979; (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride;(2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride

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