| 应用 |
An amino-acid derivative that stimulates insulin secretion |
| 产品介绍 |
Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of theβ cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs. |
| 备注 |
Nateglinide is an insulin secretagog agent that lowers blood glucose levels by stimulating insulin secretion from the pancreas. |
| 生化机理 |
该产品是一种新型的Ⅱ型糖尿病治疗药物，属于胰岛素分泌促进剂和ATP敏感性钾通道阻滞剂。具有体内起效较快，降血糖持续作用时间短等特点，而且它不抑制逆向调节激素高血糖的增加，因而可减少引发低血糖的危险性。 |
| 别名 |
N-(反式-4-异丙基环己基甲酰)-D-苯丙氨酸;;那格列奈;Fastic;Starlix;Starsis;N-[(trans-4-Isopropylcyclohexyl)carbonyl]-D-phenylalanine |
