耗材描述
- 分子式 C9H7Cl2N5
- 分子量256.09
- EC号 281-901-8
- MDL号 MFCD00865333
- PubChem编号 24278792
属性
| 熔点 | 216-218°C |
| 敏感性 | 对热和空气敏感 |
| 溶解性 | Soluble in DMSO (12 mg/mL) at 40 °C, ethanol (12 mg/mL) at 40 °C, DMF (25 mg/mL), methanol, and dilute hydrochloric acid (slightly soluble). Insoluble in water. |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A sodium channel protein inhibitor. |
| 产品介绍 | Lamotrigine是一种新型抗惊厥药剂，作用于人类血小板和大鼠脑突触体，抑制5-羟色胺(5-HT)吸收，IC50分别为240 μM和474 μM。 |
| 备注 | Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker. |
| 生化机理 | Lamotrigine is a phenyltriazine sodium channel protein inhibitor of presynaptic neurons. Studies indicate that Lamotrigine blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine. Futhermore, Lamotrigine displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents. Lamotrigine is an inhibitor of Serotonin. |
| 别名 | 6-(2,3-二氯苯基)-1,2,4-三嗪-3,5-二胺;3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪; LTG; BW430C;拉莫三嗪;GI 267119X;6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; Lamictal; Epilepax; LTG; BW430C |
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