K129651-50mgKetanserin
面议
- 阿拉丁
- 生产商
- K129651-50mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C22H22FN3O3
- 分子量395.43
- Beilstein号
- EC号
- MDL号 MFCD00083392
- PubChem编号
属性
熔点 | 228-232 °C |
溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (2 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (10 mg/ml), and methanol. |
存贮条件 | 储存温度-20°C |
描述
应用 | A selective serotonin antagonist. |
产品介绍 | Ketanserin 是一种特异性的5-HT2A 5-羟色胺受体拮抗剂,作用于大鼠和人5-HT2A,Ki为2.5 nM。 |
备注 | Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
生化机理 | Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors. Ketanserin is a selective serotonin 5-HT2/5-HT1C antagonist. It has been used to distinguish between 5-HT1D and 5-HT1B receptor subtypes. Additional studies have noted that Ketanserin is able to differentiate between recombinant human forms of these receptors with a higher affinity for 5-HT1Dα receptors compared to 5-HT1Dβ receptors. |
别名 | 酮色林; 酮舍林; 凯坦色林; 凯他色林; 3-[2-[4-(4-氟苯甲酰)-1-哌啶基]乙基]-2,4[1H,3H]-喹唑二酮;R-49945;Perketan;R-49945;3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione |
Reaxys-RN | 4913068 |
RTECS | VA1411190 |
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