D129948-1gDonepezil HCl
面议
- 阿拉丁
- 生产商
- D129948-1g
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C24H29NO3·HCl
- 分子量415.96
属性
熔点 | 220-222°C |
溶解性 | Soluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly). |
存贮条件 | 储存温度-20°C |
描述
应用 | A noncompetitive acetylcholinesterase (AChE) inhibitor. |
产品介绍 | Donepezil HCl 是一种特异性的,有效的AChE抑制剂,作用于bAChE和hAChE,IC50分别为8.12 nM和11.6 nM。 |
备注 | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
生化机理 | Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine. |
别名 | 盐酸多奈哌齐; 2,3-二氢-5,6-二甲氧基-2-{[(1-苯甲基)-4-哌啶基]甲基}-1H-茚-1-酮盐酸盐;2-(1-苄基-4-哌啶基甲基)-5,6-二甲氧基-1-二氢茚酮盐酸盐;2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride; Donepezil hydrochloride;E 2020; Aricept; E2020; E-2020;1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride(1:1) |
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