L126048-250mg(R)-(-)-Ibuprofen
面议
- 阿拉丁
- 生产商
- L126048-250mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C13H18O2
- 分子量206.28
- Beilstein号
- EC号
- MDL号 MFCD00069290
- PubChem编号
属性
沸点 | 319.64 °C/760 mmHg |
熔点 | 50.5-52.5 °C |
折光率 | 1.52 |
溶解性 | Soluble in methanol, 0.1 M NaOH, dichloromethane, and ethyl acetate. |
密度 | 1.0300 |
描述
应用 | An inhibitor of Cox-1 and Cox-2. |
产品介绍 | (R)-Ibuprofen是ibuprofen的低活性对映体。 |
生化机理 | (R)-Ibuprofen, a nonsteroidal antiinflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2. Most of the activity resides in (S)-ibuprofen. It has been observed that the inversion of R(-)-ibuprofen to the S(+) antipode occurs in rat liver but not in either serosal or mucosal sides of the small intestine. (R)-Ibuprofen’s presence can be detected in urine through mass chromatography. A liquid-chromatographic assay has been used to study the pharmacokinetics of the (S)- and (R)-Ibuprofen forms in plasma. |
别名 | (R)-布洛芬;(R)-Ibuprofen;L-Ibuprofen;(alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; R-(-)-p-Isobutylhydratropic acid; R-(-)-p-Isobutylhydratropic acid |
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