K125309-25mgKN-93
面议
- 阿拉丁
- 生产商
- K125309-25mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C26H29ClN2O4S
- 分子量599.03
属性
沸点 | 657.60° C at 760 mmHg |
折光率 | 1.63 |
溶解性 | DMSO > 25 mg/ml Ethanol > 25 mg/ml |
存贮条件 | 储存温度2-8℃ |
密度 | 1.3000 |
描述
应用 | An effective inhibitor of CaMKII phosphorylating activity |
产品介绍 | KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。 |
生化机理 |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
别名 | KN 93;KN93;N-[2-[[[3-(4-氯苯基)-2-丙烯-1-基]甲基氨基]甲基]苯基]-N-(2-羟基乙基)-4-甲氧基苯磺酰胺;KN 93;KN93;N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide |
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