B125482-10mgBMS-378806
面议
- 阿拉丁
- 生产商
- B125482-10mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C22H22N4O4
- 分子量406.43
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4receptor with EC50 of 0.85-26.5 nM in virus. |
生化机理 |
BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM. BMS-806 (BMS 378806) was proved to be specific for HIV-1, with no activity against HIV-2 or simian immunodeficiency virus. BMS-806 (BMS 378806) is active against HIV-1 isolates irrespective of chemokine receptor preference. BMS-806 (BMS 378806) binds gp120, and changes in particular gp120 amino acid residues can alter the sensitivity of the virus to BMS-806 (BMS 378806). BMS-806 (BMS 378806) potently inhibited HIV-1 infection regardless of the particular chemokine receptor used. |
别名 | (R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(4-methoxy-7H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione;(R)-1-(4-benzoyl-2-methylpiperazin-1-yl)-2-(4-methoxy-7H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione |
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