P127947-10mgPF-670462
面议
- 阿拉丁
- 生产商
- P127947-10mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C19H20FN5·2HCl
- 分子量410.32
属性
敏感性 | 对湿度敏感 |
溶解性 | Soluble in water (100 mM), and DMSO (100 mM). |
存贮条件 | 储存温度 2-8°C |
描述
应用 | A selective CK1ε and CK1δ inhibitor. |
产品介绍 | PF 670462 is a selective casein kinase, CK1ε and CK1δ inhibitor which also shows potency against 42 other kinases. In addition, PF 670462 can inhibit Period circadian protein homolog 1 (PER1) protein nuclear translocation which results in phase shifts in circadian rhythms. |
生化机理 | PF-670462 is a selective inhibitor of the δ- and ε-isoforms of casein kinase I, with IC50 values of 7.7 and 14 nM respectively, and >30 selectivity relative to 42 other kinases tested. Casein kinase Iε phosphorylates PER proteins, which are involved in setting the period of the circadian pacemaker or clock. PF-670462 is potent (IC50 7.7 nM) and effective in vivo (i.e. it induces profound phase delays in circadian periodicity). |
别名 | PF 670462;PF670462; 4-[1-环己基-4-(4-氟苯基)-1H-咪唑-5-基]-2-嘧啶胺盐酸盐;PF 670462;PF670462;4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride;4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride |
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