Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).
生化机理
Ambrisentan is an endothelin receptor type A-selective endothelin receptor antagonist. Ambrisentan is useful for pulmonary arterial hypertension (PAH).