G126387-100mgGDC-0980 (RG7422)
面议
- 阿拉丁
- 生产商
- G126387-100mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C23H30N8O3S
- 分子量498.61
属性
沸点 | ~718.6° C at 760 mmHg |
熔点 | 222-226° C |
折光率 | 1.68 |
溶解性 |
|
存贮条件 | 储存温度-20°C |
密度 | 1.4000 |
描述
应用 | A PI3K and FRAP (mTOR) kinase inhibitor |
产品介绍 | GDC-0980 (RG7422)是I型PI3K抑制剂,对PI3Kα,β,δ和γ的IC50分别为5 nM,27 nM,7 nM和14 nM,对mTOR的Ki为17 nM。 |
备注 | GDC-0980 (RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM, respectively. Also a mTOR inhibitor with Ki of 17 nM, and highly selective versus others PIKK family kinases. |
生化机理 |
GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively. |
别名 | GNE 390; GDC 0980; RG 7422;(s)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one;GNE 390; GDC 0980; RG 7422; (S)-1-(4-((2-(2-氨基嘧啶-5-基)-7-甲基-4-(吗啉-4-基)噻吩并(3,2-d)嘧啶-6-基)甲基)哌嗪-1-基)-2-羟基丙-1-酮; |
猜你喜欢
感兴趣产品