G127588-10mgGDC-0068
面议
- 阿拉丁
- 生产商
- G127588-10mg
- 现货
- 全国
规格 |
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耗材描述
- 分子式 C24H32ClN5O2
- 分子量458
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | GDC-0068(RG 7440)是泛Akt抑制剂,对Akt1/2/3的IC50分别为5 nM/18 nM/8 nM,比对PKA的抑制性高620倍。 |
备注 | GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. Phase 2. |
生化机理 |
GDC-0068 is a novel, highly selective oral ATP-competitive inhibitor designed to bind to the 3 isoforms of Akt. GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 inhibits the growth and proliferation of cancer cell lines and xenograft models, including those with loss of PTEN function, oncogenic mutations in PIK3CA, and amplification of HER2. Phase I study of GDC-0068 in patients with refractory solid tumors is ongoing. |
别名 | RG7440; GDC0068; GDC 0068; RG-7440; RG 7440; (2S)-2-(4-氯苯基)-1-(4-((5R,7R)-6,7-二氢-7-羟基-5-甲基-5H-环戊并嘧啶-4-基)-1-哌嗪基)-3-((1-甲基乙基)氨基)-1-丙酮;;Ipatasertib; RG7440; GDC0068; GDC 0068; RG-7440; RG 7440;2s)-2-(4-chlorophenyl)-1-(4-((5r,7r)-6,7-dihydro-7-hydroxy-5-methyl-5h-cyclopentapyrimidin-4-yl)-1-piperazinyl)-3-((1-methylethyl)amino)-1-propanone |
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