E125341-10mgEverolimus
面议
- 阿拉丁
- 生产商
- E125341-10mg
- 现货
- 全国
规格 |
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耗材描述
属性
溶解性 | Soluble in chloroform, methanol, DMSO (100 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (100 mg/ml). |
存贮条件 | 储存温度-20°C |
描述
应用 | An immunosuppresive inhibitor of FRAP (mTOR). |
产品介绍 | Everolimus (RAD001)是一种mTOR抑制剂,作用于FKBP12,IC50为1.6-2.4 nM。 |
备注 | Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
生化机理 | Everolimus is a macrolide derived from rapamycin with immunosuppressant properties shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that everolimus is a mTOR (FRAP) inhibitor that displays high affinity toward the intracellular receptor FKBP12. Additionally, the Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to FRAP |
别名 | 依维莫司;RAD001; SDZ-RAD; Certican; Zortress; Afinitor;RAD 001;40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl Rapamycin |
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