A126201-10mgAlogliptin

耗材描述

• 分子式 C₁₈H₂₁N₅O₂
• 分子量339.39
• Beilstein号
• EC号
• MDL号
• PubChem编号

属性

溶解性	25°C: DMSO 68 mg/mL; Water 2mg/m L; Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	Alogliptin是一种有效的，选择性的DPP-4抑制剂，IC50为<10 nM，比作用于DPP-8和DPP-9选择性高10000倍以上。
备注	Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Phase 4.
生化机理
Alogliptin 的参考资料: [1]. Feng J, et al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300. [2]. Ta NN, et al. DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis. 2010 Dec;213(2):429-35. [3]. Asakawa T, et al. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure. Life Sci. 2009
别名	阿洛利停;阿格列汀;Nesina;SYR-322;2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile

AI问答

• Alogliptin配套的仪器设备？
• Alogliptin可以搭配的相关耗材试剂？
• Alogliptin的详细规格参数是什么？
• Alogliptin的使用的注意事项？

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