P125184-500mgPazopanib
面议
- 阿拉丁
- 生产商
- P125184-500mg
- 现货
- 全国
规格 |
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耗材描述
属性
溶解性 |
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存贮条件 | 储存温度-20°C |
描述
应用 | A potent and selective inhibitor of Flk-1, PDGFR and c-kit |
产品介绍 | Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which are key proteins responsible for tumor growth and angiogenesis. |
备注 | Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. |
生化机理 | Pazopanib is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
别名 | VEGFR抑制剂;帕唑帕尼;GW 786034;Votrient;GW-786034;GW786034;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide |
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