S129830-100mgSANT-1
面议
- 阿拉丁
- 生产商
- S129830-100mg
- 现货
- 全国
规格 |
---|
耗材描述
- 分子式 C23H27N5
- 分子量373.49
属性
熔点 | 109-111° C |
折光率 | 1.62 |
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death. |
产品介绍 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
备注 | SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
生化机理 | SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells. SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency. |
别名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺;(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine;(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
标识符号 | GHS07 |
信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
WGK德国 | 3 |
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